Results
| PMID | 26342048 |
| Gene Name | IL37 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2016 Feb;23(2):244-8. doi: 10.1177/1933719115602775. Epub 2015 Sep 3. Jiang, Jian-Fa| Deng, Yan| Xue, Wei| Zheng, Ting-Ping| Sun, Ai-Jun Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.| Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chine INTRODUCTION: Endometriosis is a chronic inflammatory condition. Interleukin (IL) 37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study investigated the gene and protein expression of IL-37 in the eutopic and ectopic endometrium of women with ovarian endometriosis and in the endometrium of patients without endometriosis. METHODS: Eutopic and ectopic endometria (n = 24) were collected from patients with ovarian endometriosis, and control endometria (n = 15) were obtained from women without endometriosis. Quantitative real-time polymerase chain reaction was used to measure the gene expression levels of IL-37, and immunohistochemistry was performed to assess the protein expression levels of IL-37. RESULTS: The gene and protein expression levels of IL-37 in both eutopic and ectopic endometrium of women with ovarian endometriosis were significantly higher than in the endometrium of patients without endometriosis. Compared to the eutopic endometrium of patients with ovarian endometriosis, IL-37 gene and protein expression levels were significantly higher in the ectopic endometrium. CONCLUSION: These findings suggest that increased expression of IL-37 was present in eutopic and ectopic endometrium of women with ovarian endometriosis, which might be involved in the inflammatory process of endometriomas. Mesh Terms: Adult| Endometriosis/genetics/*metabolism/pathology| Endometrium/*metabolism/pathology| Female| *Gene Expression| Humans| Interleukin-1/genetics/*metabolism| Ovarian Diseases/genetics/*metabolism/pathology| RNA, Messenger/genetics/metabolism|DA 20 |
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